PHARMACOLOGICAL METHODS OF PREVENTING STRESS-INDUCED STATES IN THE EXPERIMENT

Frantsuzova Tatyana Ivanovna, Anesthetist-expert in resuscitation, Municipal clinical hospital № 4 (Saransk), tatiano.fran@mail.ru
Chistyakov Sergey Ivanovich, Doctor of medicine, professor, sub-department of general surgery and anesthesiology, Medical institute, Mordovia state university named after N. P. Ogarev (Saransk), chist62@mail.ru
Balashov Vladimir Pavlovich, Doctor of biological sciences, professor, head of sub-department of histology, cytology and embryology, Medical institute, Mordovia state university named after N. P. Ogarev (Saransk), bvp63@yandex.ru
Ovsyannikova Lyudmila Anatolyevna, Candidate of medical sciences, associate professor, sub-department of pharmacology, First Moscow state medical university named after I. M. Sechenov, obg555@list.ru

615.27:612.017

During our work was found stress-protections activity of picamilon, mildronat and dalargin. For a level of stress-protections these preparations are the best than a diazepam. The stress-protection of preparations is shown on vital level – they raise survival rate of mice in the conditions of chronic stress. Positively influence indicators of behavioural activity. Reduce a damage rate mucous of gastroduodenals’ zones. Interfere with oppression of cages of nonspecific immunity, activate their protective functions. The received results give the chance their uses as stresses-protectors in clinical practice.

stress, diazepam, dalargin, picamilon, mildronat.